Novel Mechanism for Negatively Regulating Rho - Kinase ( ROCK ) Signaling through Coronin 1 B in Neuregulin 1 ( NRG - 1 ) induced Tumor Cell Motility ”

نویسندگان

  • Manish K. Rana
  • Rebecca A. Worthylake
چکیده

Background: Negative regulatory mechanisms of ROCK signaling are poorly understood. We have discovered a novel mechanism to attenuate ROCK signaling. Results: Coronin1B is a novel binding partner of ROCK2 that inhibits ROCK signaling to myosin. Conclusion: Coronin1B regulates ROCK by a novel signal attenuation mechanism. Significance: Coronin1B attenuation of ROCK signaling is associated with NRG-1 induced tumor cell motility.

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تاریخ انتشار 2012